University of Oxford
Rabe Research Group
Search

Publications

 

  1. Drop-on-fixed-target reaction initiation approach for serial and time-resolved crystallography
    J. J. A. G. Kamps, P. Hinchliffe, J. Glerup, E. I. Freeman, P. A. Lang, C. L. Tooke, M. Beer, L. Parkinson, D. H. Gu, S. Park, N. Devenish, T. Zhou, A. Shilova, S. Kaur, P. Rabe, C. J. Schofield, J. Spencer, J. Park, R. L. Owen, A. M. Orville, P. Aller

    IUCrJ, 2026, 13, 471-484.                          

     

  2. Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-β-hydroxylase
    M. de Munnik, A. Brasnett, T. Zhou, W. Myers, Y. Wang, K. Chatterjee, A. Tumber, S. Marshall, P. Simon, P. Aller, A. Shilova, D. Axford, H. Makita, D. Paley, V. Tiwari, A. Stead, S. Dehe, H. Sanchez, D. Rosenberg, R. Alonso-Mori, A. Bhowmick, J. Yano, V. Yachandra, J. Park, S. Park, A. Orville, L. Brewitz, J. F. Kern, C. J. Schofield, P. Rabe

    Nat. Commun., 2026, 17, 4267.
     
  3. KDM3A catalysed formation of hydroxylated l-lysine on histone H3K9
    R. Belle, J. P. Bukowski, R. Schiller, R. Cutler, E. Salah, R. S. Dawber, A. Tumber, J. Bonnici, J. Kindrick, L. Serrano, P. Rabe, C. Johannson, M. H. Ruchaud, R. J. Hopkinson, W. D. Figg, P. E. Brennan, D. R. Moled, S. Sidoli, A. Kawamura, C. J. Schofield

    Nat. Chemistry, 2026, 18, 823–834.
     
  4. Structural and functional consequences of aspartate/asparag- -hydroxylasevariants causing Traboulsi Syndrome 
    C. X. Hou, A. Brasnett , P. Rabe, C. J. Schofield, L. Brewitz

    J. Biol. Chem, 2026 , 302 , 211008.
     
  5. Targetting Mycrobacterial Transpeptidases: Evaluating the Role of Ldt and PBP Inhibition in Suppressing Mycobacterium smagmatis
    M. de Munnik, K. Calvopiña , P. Rabe, C. J. Schofield

    Antimicrobial Agents Chemother, 2025, 69,  e0012625.
     
  6. Filamin C dimerisation is regulated by HSPB7
    Z. Wang, G. Cao, M. P. Collier, X. Qui, S. Broadway-Stringer, D. Saman, J. Z. Y. Ng, N. Sen, A. J. Azad, C. Hooper, J. Zimmermann, M. A. McDonough, J. Brem, P. Rabe, H. Song, T. R. Alderson, C. J. Schofield, J. R. Bolla, K. Djinovic-Carugo, D. O. Fürst, B. Warscheid, M. T. Degiacomi, T. M. Allison, G. K. A. Hochberg, C. V. Robinson, K. Gehmlich, J. L. P. Benesch

    Nat. Commun ., 2025, 16, 4090.
     
  7. JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships
    J. Bonnici, R.Oueni, E. Salah, C. Johansson, E. Pires, M. Abboud, R. S. Dawber, P. Rabe, H Sarac, C. J. Schofield, A. Kawamura

    Commun. Biol., 2024 , 7, 1583.
     
  8. Biochemical and crystallographic studies of l,d-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate
    M. de Munnik, P. A. Lang, K. Calvopiña , P. Rabe, J. Brem, C. J. Schofield

    Commun. Biol., 2024 , 7, 1173.
     
  9. Methods for production and assaying catalysis of isolated recombinant human aspartate/asparagine-β-hydroxylase
    L. Brewitz, A. Brasnett, L. I. Schnaubelt, P. Rabe, A. Tumber, C. J. Schofield

    Methods Enzymol., 2024 , 704, 313- 344.
     
  10. Interactions of hydrolyzed β-lactams with the L1 metallo-β-lactamase: Crystallography supports stereoselective binding of cephem/carbapenem products
    P. Hinchliffe, K. Calvopiña, P. Rabe, M. F. Mojica, C. J. Schofield, G. I. Dmitrienko, R. A. Bonomo, A. J. Vila, J. Spencer

    J. Biol. Chem, 2023 , 299, 104606.
     
  11. Natural and synthetic 2-oxoglutarate derivatives are substrates for oncogenic variants of human isocitrate dehydrogenase 1 and 2
    X. Liu, R. Reinbold, S. Liu, R. A. Herold, P. Rabe, S. Duclos, R. B. Yadav, M. I. Abboud, S. Thieffine, F. A. Armstrong, L. Brewitz, C. J. Schofield

    J. Biol. Chem, 2023 , 299, 102873.
     
  12. Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane
    N. Frank, J. Nugent, B. R. Shire, H. D. Pickford, P. Rabe, A. J. Sterling, T. Zarganes-Tzitzikas, T. Grimes, A. L. Thompson, R. C. Smith, C. J. Schofield, P. E. Brennan, F. Duarte, E. A. Anderson

    Nature, 2022, 611, 721-726.
     
  13. Spectroscopic studies reveal details of substrate-induced conformational changes distant from the active site in isopenicillin N synthase
    P. Rabe, C. C. Walla, N. K. Goodyear, J. Welsh, R. Southwart, I. Clifton, J. D.S. Linyard, A. Tumber, T.D.W. Claridge, W. K. Myers, C. J. Schofield

    J. Biol. Chem. 2022, 102249.
     
  14. Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors
    R. Reinbold, I. C. Hvinden, P. Rabe, R. A. Herold, A. Finch, J. Wood, M. Morgan, M. Staudt, I. J. Clifton, F. A. Armstrong, J. S. O. McCullagh, J. Redmond, C. Bardella, M. I. Abboud, C. J. Schofield

    Nat. Commun . 2022, 13, 4785.
     
  15. Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors
    P. A. Lang, R. Raj, A. Tumber, C. T. Lohans, P. Rabe, C. V. Robinson, J. Brem, C. J. Schofield

    Proc. Natl. Acad. Sci. USA. 2022, 119, e2117310119.
     
  16. An on-demand, drop-on-drop method for studying enzyme catalysis by serial crystallography
    A. Butryn, P. S. Simon, P. Aller, P. Hinchliffe, R. N. Massad, G. Leen, C. L. Tooke, I. Bogacz, I. Kim, A. Bhowmick, A. S. Brewster, N. E. Devenish, J. Brem, J. J. A. G. Kamps, P. A. Lang, P. Rabe, D. Axford, J. H. Beale, B. Davy, A. Ebrahim, J. Orlans, S. L. S. Storm, T. Zhou, S. Owada, R. Tanaka, K. Tono, G. Evans, R. L. Owen, F. A. Houle, N. K. Sauter, C. J. Schofield, J. Spencer, V. K. Yachandra, J. Yano, J. F. Kern, A. M. Orville

    Nat. Commun. 2021, 12, 4461.
     
  17. Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates
    A. J. M. Farley, Y. Ermolovich, K. Calvopiña, P. Rabe, T. Panduwawala, J. Brem,  F. Björkling, C. J. Schofield

    ACS Infect. Dis. 2021 , 7, 1809-1817.
     
  18. X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis
    P. Rabe, J. J. A. G. Kamps, K. D. Sutherlin, J. D. S. Linyard, P. Aller, C. C. Pham, H. Makita, I. Clifton, M. A. McDonough, T. M. Leissing, D. Shutin, P. A. Lang, A. Butryn, J. Brem, S. Gul, F. D. Fuller, In-Sik Kim, M. Hon Cheah, T. Fransson, A. Bhowmick, I. D. Young, L. O'Riordan, A. S. Brewster, I. Pettinati, M. Doyle, Y. Joti, S. Owada, K. Tono, A. Batyuk, M. S. Hunter, R. Alonso-Mori, U. Bergmann, R. L. Owen, N. K. Sauter, T. D. W. Claridge, C. V. Robinson, V. K. Yachandra, J. Yano, J. F. Kern, A. M. Orville, C. J. Schofield

    Science Advances, 2021 , 7, DOI: 10.1126/sciadv.abh0250.
     
  19. The Termite Fungal Cultivar Termitomyces Combines Diverse Enzymes and Oxidative Reactions for Plant Biomass Conversion
    F. Schalk, C. Gostinčar, N. Kreuzenbeck, B. Schantz-Conlon, E. Sommerwerk, P. Rabe, I. Burkhardt, T. Krüger, O. Kniemeyer, A. Brakhage, N. Gunde-Cimerman, W. De Beer, J. Dickschat, M. Poulsen, C. Beemelmanns

    mBio. 2021, 12, e03551-20.
     
  20. Faropenem reacts with serine and metallo-β-lactamases to give multiple products
    A. Lucic, P. Hinchliffe, T. R Malla, C. L. Tooke, J. Brem, K. Calvopiña, C. T. Lohans, P. Rabe, M. A McDonough, T. Armistead, A. M Orville, J. Spencer, C. J Schofield

    Eur. J. Med. Chem. 2021, 215, 113257.
     
  21. Anaerobic fixed-target serial crystallography
    P. Rabe, J. H. Beale, A. Butryn, P. Aller, A. Dirr, P. A. Lang, D. N. Axford, S. B. Carr, T. M. Leissing, M. A. McDonough, B. Davy,b A. Ebrahim, J. Orlans, S. L. S. Storm, A. M. Orville, C. J. Schofield, R. L. Owen

    IUCrJ. 2020 , 7, 901-912.
     
  22. A terpene synthase-cytochrome P450 cluster in Dictyostelium discoideum produces a novel trisnorsesquiterpene
    X. Chen, K. Luck, P. Rabe, C. Qd Dinh, G. Shaulsky, D. R Nelson, J. Gershenzon, J. S Dickschat, T. G Köllner, F. Chen

    Elife. 2019, 8, e44352.
     
  23. Substrate promiscuity of enzymes from the sesquiterpene biosynthetic pathways from Artemisia annua and Tanacetum parthenium allows for novel combinatorial sesquiterpene production
    A. Beyraghdar Kashkooli, A. van der Krol, P. Rabe, J. S. Dickschat, H. Bouwmeester

    Metab. Eng . 2019, 54, 12-23.
     
  24. The EI-MS Fragmentation Mechanisms of Bacterial Sesquiterpenes and Diterpenes
    J. Rinkel, P. Rabe, J. S. Dickschat

    Eur. J. Org. Chem . 2019, 351-359.
     
  25. Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata
    J. Rinkel, L. Lauterbach, P. Rabe, J. S. Dickschat
    Angew. Chem. Int. Ed . 2018, 57, 3238-3241.
     
  26. Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
    P. Rabe, J. J. A. G. Kamps, C. J. Schofield, C. T. Lohans
    Nat. Prod. Rep. 2018, 35, 735-756.
     
  27. 18-Hydroxydolabella-3,7-diene synthase - a diterpene synthase from Chitinophaga pinensis
    J. S. Dickschat, J. Rinkel, P. Rabe, A. Beyraghdar Kashkooli, H. J. Bouwmeester

    Beilstein J. Org. Chem. 2017, 13, 1770-1780.
     
  28. Mechanisms of the Diterpene Cyclases β-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus
    J. Rinkel, P. Rabe, X. Chen, T. G. Köllner, F. Chen, J. S. Dickschat

    Chem. Eur. J. 2017 , 23, 10501-10505.
     
  29. The GATA-Type Transcription Factor Csm1 Regulates Conidiation and Secondary Metabolism in Fusarium fujikuroi
    E.-M. Niehaus, J. Schumacher, I. Burkhardt, P. Rabe, M. Münsterkötter, U. Güldener, J. S. Dickschat, B. Tudzynski

    Front. Microbiol . 2017, 8, 1175.
     
  30. Isoafricanol synthase from Streptomyces malaysiensis
    P. Rabe, M. Samborskyy, P. F. Leadlay, J. S. Dickschat

    Org. Biomol. Chem . 2017, 15, 2353-2358.
     
  31. Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase
    P. Rabe, J. Rinkel, E. Dolja, T. Schmitz, B. Nubbemeyer, T. H. Luu, J. S. Dickschat

    Angew. Chem. Int. Ed. 2017, 56, 2776-2779.
     
  32. A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus
    J. Rinkel, P. Rabe, L. zur Horst, J. S. Dickschat

    Beilstein J. Org. Chem. 2016, 12, 2317-2324.
     
  33. Terpene Cyclases from Social Amoebae
    P. Rabe, J. Rinkel, B. Nubbemeyer, T. G. Köllner, F. Chen, J. S. Dickschat

    Angew. Chem. Int. Ed. 2016, 55, 15420-15423.
     

  34. Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations
    J. Rinkel, P. Rabe, P. Garbeva, J. S. Dickschat

    Angew. Chem. Int. Ed. 2016, 55, 13593-13596.
     

  35. Terpene synthase genes in eukaryotes beyond plants and fungi: Occurrence in social amoebae
    X. Chen, T. G. Köllner, Q. Jia, A. Norris, B. Santhanam, P. Rabe, J. S. Dickschat, G. Shaulsky, J. Gershenzon, F. Chen

    Proc. Natl. Acad. Sci. USA. 2016, 113, 12132-12137.
     
  36. Mechanistic investigations on six bacterial terpene cyclases
    P. Rabe, T. Schmitz, J. S. Dickschat

    Beilstein J. Org. Chem. 2016, 12, 1839-1850.
     
  37. The EIMS fragmentation mechanisms of the sesquiterpenes corvol ethers A and B, epi-cubebol and isodauc-8-en-11-ol
    P. Rabe, J. S. Dickschat

    Beilstein J. Org. Chem. 2016, 12, 1380-1394.
     
  38. Pristinol, a Sesquiterpene Alcohol with an Unusual Skeleton from Streptomyces pristinaespiralis
    T. A. Klapschinski, P. Rabe, J. S. Dickschat

    Angew. Chem. 2016, 128, 10296-10299; Angew. Chem. Int. Ed. 2016, 55, 10141-10144.
     
  39. Position-Specific Mass Shift Analysis: A Systematic Method for Investigating the EI-MS Fragmentation Mechanism of epi-Isozizaene
    P. Rabe, T. A. Klapschinski, J. S. Dickschat

    ChemBioChem 2016, 17, 1333-1337.
     
  40. Experimental and Theoretical Studies on Corvol Ether Biosynthesis
    P. Rabe, A. Janusko, B. Goldfuss, J. S. Dickschat

    ChemBioChem 2016, 17, 146-149.
     
  41. A method for investigating the stereochemical course of terpene cyclisations
    P. Rabe, J. Rinkel, T. A. Klapschinski, L. Barra, J. S. Dickschat

    Org. Biomol. Chem. 2016, 14, 158-164.
     
  42. Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by 13C-Labeling Experiments
    P. Rabe, L. Barra, J. Rinkel, R. Riclea, C. A. Citron, T. A. Klapschinski, A. Janusko, J. S. Dickschat

    Angew. Chem. 2015, 127, 13649-13653; Angew. Chem. Int. Ed. 2015, 54, 13448-13451.
     
  43. Structures and Biosynthesis of Corvol Ethers-Sesquiterpenes from the Actinomycete Kitasatospora setae
    P. Rabe, K. A. K. Pahirulzaman, J. S. Dickschat

    Angew. Chem. 2015, 127, 6139-6143; Angew. Chem. Int. Ed. 2015, 54, 6041-6045.
     
  44. The chemical biology of dimethylsulfoniopropionate
    J. S. Dickschat, P. Rabe, C. A. Citron

    Org. Biomol. Chem. 2014, 13, 1954-1968.
     
  45. Synthesis of Isotopically Labelled Oligoprenyl Diphosphates and Their Application in Mechanistic Investigations of Terpene Cyclases
    C. A. Citron, P. Rabe, L. Barra, C. Nakano, T. Hoshino, J. S. Dickschat

    Eur. J. Org. Chem. 2014, 7684-7691.
     
  46. Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid
    P. Rabe, T. A. Klapschinski, N. L. Brock, C. A. Citron, P. D'Alvise, L. Gram, J. S. Dickschat

    Beilstein J. Org. Chem. 2014, 10, 1796-1810.
     
  47. Induced-Fit Mechanism in Class I Terpene Cyclases
    P. Baer,* P. Rabe,* K. Fischer, C. A. Citron, T. A. Klapschinski, M. Groll, J. S. Dickschat

    Angew. Chem. 2014, 126, 7783-7787; Angew. Chem. Int. Ed. 2014, 53, 7652-7656.
     
  48. An Improved Technique for the Rapid Chemical Characterisation of Bacterial Terpene Cyclases
    J. S. Dickschat, K. A. K. Pahirulzaman, P. Rabe, T. A. Klapschinski

    ChemBioChem 2014, 15, 810-814.
     
  49. Hedycaryol Synthase in Complex with Nerolidol Reveals Terpene Cyclase Mechanism
    P. Baer,* P. Rabe,* C. A. Citron, C. C. de Oliveira Mann, N. Kaufmann, M. Groll, J. S. Dickschat

    ChemBioChem 2014, 15, 213-216.
     
  50. Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis
    T. Wang, P. Rabe, C. A. Citron, J. S. Dickschat

    Beilstein J. Org. Chem. 2013, 9, 2767-2777.
     
  51. Volatile Terpenes from Actinomycetes: A Biosynthetic Study Correlating Chemical Analyses to Genome Data
    P. Rabe, C. A. Citron, J. S. Dickschat

    ChemBioChem 2013, 14, 2345-2354.
     
  52. Rapid Chemical Characterization of Bacterial Terpene Synthases
    P. Rabe, J. S. Dickschat

    Angew. Chem. 2013, 125, 1855-1857; Angew. Chem. Int. Ed. 2013, 52, 1810-1812.
     
  53. The Scent of Bacteria: Headspace Analysis for the Discovery of Natural Products
    C. A. Citron, P. Rabe, J. S. Dickschat

    J. Nat. Prod. 2012, 75, 1765-1776.
     
  54. The Stereochemical Course and Mechanism of the IspH Reaction
    C. A. Citron, N. L. Brock, P. Rabe, J. S. Dickschat

    Angew. Chem. 2012, 124, 4129-4133; Angew. Chem. Int. Ed. 2012, 51, 4053-4057.